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. 2015 Mar 16;10(3):e0121211. doi: 10.1371/journal.pone.0121211

Table 3. The accuracy by which molecularly selected patient trials can be distinguished from all-comer trials using two alternative endpoints.

Endpoint with the most accurate cutoff level Molecularly selected patient trials (n = 8) All-comer trials (n = 10) Sensitivity Specificity AUC
PFS-HR 100% 100% 1.00
< 0.60 8 0
≥ 0.60 0 10
Odds ratio for the overall response 88% 90% 0.95
≥ 3.40 7 1
< 3.40 1 9
Both the PFS-HR and odds ratio for the overall response
< 0.60 and ≥ 3.40 7 0
Other 1 10
Either the PFS-HR or the odds ratio for the overall response
< 0.60 or ≥ 3.40 8 1
Other 0 9

AUC, area under the receiver operating characteristic curve.