Table 3.
Plasma concentrations of low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp(a)) in patients with severe hypercholesterolemia before, in first month, and during steady state of chronic lipoprotein apheresis (LA)
| LDL-C | Before LA | First month | Steady state | Mean total LDL-C reduction (%) |
| Cmax before LA (mg/dL) | Not done | 154.7 ± 51.4 | 148.8 ± 43.9 | |
| Cmin after LA (mg/dL) | Not done | 63.1 ± 26.8 | 48.9 ± 18.6 | |
| Reduction by LA (%) | Not done | 58.7 ± 12.0 |
66.7 ± 10.8 (p < 0.0001) |
|
| Interval mean level (mg/dL) | 176.4 ± 67.0 | 128.1 ± 42.6 | 119.8 ± 34.7 |
32.1 ± 19.6 (p < 0.0001) |
| Lp(a) | Before LA | First month | Steady state | Mean total Lp(a) reduction (%) |
| Cmax before LA (mg/dL) | Not done | 52.5 ± 55.4 | 40.2 ± 38.9 | |
| Cmin after LA (mg/dL) | Not done | 23.4 ± 25.2 | 14.0 ± 12.6 | |
| Reduction by LA (%) | Not done | 54.6 ± 20.7 |
65.2 ± 30.7 (p < 0.0001) |
|
| Interval mean level (mg/dL) | 75.0 ± 64.5 | 48.3 ± 47.2 | 32.7 ± 31.0 |
56.4 ± 20.5 (p < 0.0001) |
There have been patients in whom no Lp(a) was detectable, but they have not been separately recorded