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Mechanism of adsorption of COL1A1/mfp-3 to TiO2. Mfp-3 is pre-adsorbed to TiO2 before introducing COL1A1 (left), which adsorbs to surface-bound mfp-3. In contrast, COL1A1 by itself is not adsorbed to TiO2 (right) but can be rescued for adsorption by mfp3-injection. Mfp-3 either binds to COL1A1 creating a sticky complex or to the TiO2 surface.
