Fig. 1.

Sleep-wake patterns in 5XFAD and WT littermates under baseline conditions. Average percent sleep across 3 consecutive days analyzed over (A) 24 hours, (B) dark phase, and (C) light phase. Female but not male 5XFAD mice show reduction in sleep duration across 24 h and during the dark phase. (D to F) depicts average bout length in seconds (s) over (D) 24 h (E) dark phase, and (F) light phase. 5XFAD mice of both sexes had shorter average bout lengths across all phases in both the sexes. Values represent means ± SEM. *: P < 0.05; **P <0.01, ***P < 0.001