Table 2. Free energy barriers for the TRDGs of the AMPA ABDs. States are denoted by their mean efficiencies. Barrier heights are measured relative to the lowest energy state for each system.

Branch 1	Branch 2	Barrier height (kcal/mol)
Glutamate
0.58	0.69, 0.85, 0.97	9.05
0.69	0.85, 0.97	8.95
0.85	0.97	8.75
Nitrowillardiine
0.47	0.63, 0.74, 0.84, 0.93	9.59
0.93	0.63, 0.74, 0.84	8.79
0.63	0.74, 0.84	8.45
0.74	0.84	8.42
UBP282 antagonist
0.11	0.32, 0.51, 0.62, 0.76, 0.88	8.54
0.32	0.51, 0.62, 0.76, 0.88	9.07
0.51	0.62, 0.76, 0.88	8.22
0.62	0.76, 0.88	8.21
0.76	0.88	7.85