Table 1.

Basic lymphocyte subpopulations and regulatory T-cells subsets in patients and controls

(Sub)population	Controls	PT group B	PT group C	PT group D	PT group E	p (Gr B)	p (Gr C)	p (Gr D)	p (Gr E)
	N = 19 (mean ± SD)	N = 22 (mean ± SD)	N = 11 (mean ± SD)	N = 5 (mean ± SD)	N = 6 (mean ± SD)	(Log-trans.)	(Log-trans.)	(Log-trans.)	(Log-trans.)
WBC count (×109/L)	7.15 ± 1.31	6.13 ± 2.42	5.95 ± 2.39	4.32 ±1.15	7.95 ± 1.95	0.036	0.029	<0.001	n.s.
Abs. lymphoc. count × (109/L)	2.07 ± 0.49	2.05 ± 0.98	1.73 ± 0.80	1.59 ± 0.58	3.05 ± 0.84	n.s.	0.059	0.048	0.006
CD3+ (%)	71.8 ± 6.21	70.3 ± 11.3	70.3 ± 13.1	74.7 ± 6.00	66.6 ± 9.70	n.s.	n.s.	n.s.	n.s.
CD3+ (abs. count ×109/L)	1.51 ± 0.39	1.40 ± 0.58	1.15 ± 0.37	1.21 ± 0.50	2.00 ± 0.53	n.s.	0.023	n.s.	0.052
CD3+CD4+ (%)	49.4 ± 5.72	40.8 ± 9.78	41.8 ± 11.0	43.7 ± 6.1	36.6 ± 8.3	0.002	0.013	n.s.	<0.001
CD3+CD4+ (abs. count ×109/L)	1.04 ± 0.28	0.77 ± 0.33	0.67 ± 0.21	0.72 ± 0.34	1.08 ± 0.29	0.011	<0.001	0.022	n.s.
CD3+CD8+ (%)	18.4 ± 3.76	23.8 ± 7.99	21.2 ± 7.83	24.8 ± 6.32	27.6 ± 7.84	0.010	n.s.	0.018	0.001
CD3+CD8+ (abs. count ×109/L)	0.38 ± 0.11	0.48 ± 0.32	0.35 ± 0.12	0.40 ± 0.18	0.85 ± 0.40	n.s.	n.s.	n.s.	<0.001
CD4+/CD8+ ratio	2.85 ± 0.80	1.91 ± 0.76	2.18 ± 0.86	1.88 ± 0.48	1.45 ± 0.49	<0.001	0.018	0.006	<0.001
CD20+ (%)	12.3 ± 3.18	13.1 ± 8.34	11.3 ± 4.12	10.9 ± 3.51	18.4 ± 13.5	n.s.	n.s.	n.s.	n.s.
CD20+ (abs. count ×109/L)	0.23 ± 0.11	0.26 ± 0.18	0.20 ± 0.10	0.14 ± 0.04	0.45 ± 0.23	n.s.	n.s.	0.015	0.035
CD4+DR+ (%)	2.29 ± 0.69	2.67 ± 2.46	1.70 ± 1.23	3.23 ± 2.50	4.00 ± 3.50	n.s.	0.032	n.s.	n.s.
CD4+DR+ (abs. count ×106/L)	48.1 ± 15.1	54.3 ± 50.8	28.5 ± 15.7	51.9 ± 50.8	103.7 ± 56.4	n.s.	0.003	n.s.	0.003
CD4+CD25+ (% as CD4+ subset)	4.36 ± 1.03	6.62 ± 6.17	3.97 ± 1.30	7.10 ± 4.98	11.1 ± 9.10	n.s.	n.s.	n.s.	0.002
CD4+CD25+ (%)	1.01 ± 0.39	0.60 ± 0.36	0.59 ± 0.36	0.71 ± 0.22	0.42 ± 0.28	0.027	0.020	n.s.	0.005
CD4+CD25+ (abs. count ×106/L)	20.4 ± 9.1	10.7 ± 6.9	9.6 ± 7.09	9.3 ± 2.97	11.3 ± 5.96	0.007	0.009	n.s.	0.016
CD8+DR+ (%)	1.92 ± 0.67	3.69 ± 2.92	2.41 ± 1.46	3.17 ± 2.31	6.38 ± 3.55	0.019	n.s.	n.s.	<0.001
CD8+DR+ (abs. count ×106/L)	41.3 ± 17.2	87.7 ± 111	40.5 ± 24.7	56.5 ± 54.1	201 ± 155	n.s.	n.s.	n.s.	<0.001
CD8+DR+ (% as CD8+ subset)	11.1 ± 4.13	15.3 ± 8.56	11.9 ± 6.40	14.9 ± 7.51	23.1 ± 8.26	n.s.	n.s.	n.s.	0.009
CD4+CD25+dim (%)	0.78 ± 0.34	0.50 ± 0.30	0.50 ± 0.36	0.60 ± 0.20	0.35 ± 0.23	0.033	0.085	n.s.	0.074
CD4+CD25+dim (abs. count ×106/L)	17.1 ± 7.7	7.7 ± 6.3	8.7 ± 6.8	7.9 ± 2.7	9.3 ± 4.9	0.007	0.033	n.s.	n.s.
CD4+ CD25+dim (% as CD4+ subset)	2.29 ± 0.74	1.51 ± 0.74	1.48 ± 0.79	1.84 ± 0.56	1.16 ± 0.60	0.014	0.027	n.s.	0.042
CD4+CD25+dim FOXP3+ (%)	0.43 ± 0.23	0.24 ± 0.17	0.26 ± 0.21	0.22 ± 0.04	0.21 ± 0.16	0.021	0.030	0.041	n.s.
CD4+CD25+dimFOXP3+ (abs. count ×106/L)	9.79 ± 5.47	4.75 ± 4.01	4.88 ± 4.58	3.07 ± 1.13	5.65 ± 3.58	0.008	0.064	0.045	n.s.
CD4+CD25+high (%)	0.15 ± 0.06	0.10 ± 0.05	0.11 ± 0.06	0.11 ± 0.04	0.07 ± 0.05	0.039	n.s.	n.s.	0.029
CD4+CD25+high (abs. count)	3.10 ± 1.46	2.09 ± 1.28	1.92 ± 1.36	1.40 ± 0.41	1.98 ± 1.22	0.016	0.038	0.042	n.s.
CD4+CD25+highFOXP3+ (%)	0.14 ± 0.05	0.08 ± 0.04	0.09 ± 0.05	0.08 ± 0.03	0.06 ± 0.04	0.036	0.030	0.054	0.028
CD4+CD25+highFOXP3+ (abs. count)	2.90 ± 1.28	1.57 ± 1.12	1.68 ± 1.31	1.07 ± 0.31	1.55 ± 0.89	0.019	0.028	0.031	n.s.
FOXP3+ (on CD4+CD25+dim %)	56.9 ± 17.5	50.2 ± 19.4	50.5 ± 19.2	39.1 ± 9.90	57.6 ± 7.46	n.s.	n.s.	n.s.	n.s.
FOXP3+ (on CD4+CD25+high, %)	90.2 ± 6.8	81.9 ± 11.8	83.9 ± 8.7	79.5 ± 16.4	78.9 ± 2.1	0.031	0.083	n.s.	0.021