Table 2.
Intracellular cytokine expression following mitogenic stimulation
| % on CD4+ or CD8+ cells | Control Gr I | PT Gr II | PT Gr III | PT Gr IV | p value (log transformed) | ||
|---|---|---|---|---|---|---|---|
| N = 10 (mean ± SD) | N = 15 (mean ± SD) | N = 9 (mean ± SD) | N = 6 (mean ± SD) | I vs. II | I vs. III | I vs. IV | |
| CD4+IFNγ+ | 22.2 ± 7.10 | 39.3 ± 12.0 | 34.4 ± 11.5 | 46.8 ± 8.4 | <0.001 | 0.016 | <0.001 |
| MFI of IFNγ on CD4+ cells | 3004 ± 53.2 | 3144 ± 122.7 | 3122 ± 136 | 3177 ± 89.3 | 0.005 | 0.036 | <0.001 |
| CD8+IFNγ+ | 46.0 ± 14.2 | 65.3 ± 22.8 | 53.4 ± 21.4 | 83.2 ± 8.9 | 0.023 | n.s. | <0.001 |
| MFI of IFNγ on CD8+ cells | 3044 ± 110 | 3064 ± 54.5 | 3059 ± 46.4 | 3071 ± 64.2 | n.s. | n.s. | n.s. |
| CD4+IL13+ | 1.21 ± 0.95 | 1.26 ± 0.79 | 0.91 ± 0.75 | 1.62 ± 0.69 | n.s. | n.s. | n.s. |
| CD4+IL4+ | 0.84 ± 0.32 | 1.03 ± 0.54 | 1.05 ± 0.54 | 1.13 ± 0.54 | n.s. | n.s. | n.s. |
| CD4+IL10+ | 1.03 ± 0.49 | 1.15 ± 0.71 | 1.21 ± 0.84 | 1.14 ± 0.41 | n.s. | n.s. | n.s. |