Table 4.
Relationships between Quartiles of the Short IBD Questionnaire in Crohn’s Disease (n=6689) and Ulcerative/indeterminate colitis (n = 3945) and PROMIS Scores
| PROMIS# Domain | Quartile 1 SIBDQ& ≤ 4 |
Quartile 2 SIBDQ& 4.1–5.0 |
Quartile 3 SIBDQ& 5.1–5.8 |
Quartile 4 SIBDQ& ≥ 5.9 |
P^ | |
|---|---|---|---|---|---|---|
| Crohn’s disease | Anxiety Mean (SD) | 61 (8) | 55 (8) | 51 (8) | 45 (7) | <.0001 |
| Depression Mean (SD) | 60 (9) | 53 (8) | 48 (7) | 44 (5) | <.0001 | |
| Fatigue Mean (SD) | 67 (7) | 59 (8) | 53 (8) | 45 (8) | <.0001 | |
| Sleep Disturbance Mean (SD) | 58 (8) | 54 (7) | 51 (7) | 46 (7) | <.0001 | |
| Social Role Satisfaction Mean (SD) | 39 (7) | 46 (7) | 51 (7) | 57 (8) | <.0001 | |
| Pain Interference Mean (SD) | 63 (7) | 55 (8) | 49 (8) | 44 (6) | <.0001 | |
| Ulcerative colitis/Indeterminate colitis | Anxiety Mean (SD) | 62 (8) | 56 (8) | 51 (8) | 46 (7) | <.0001 |
| Depression Mean (SD) | 60 (9) | 54 (8) | 49 (7) | 44 (5) | <.0001 | |
| Fatigue Mean (SD) | 65 (8) | 58 (8) | 52 (8) | 44 (8) | <.0001 | |
| Sleep Disturbance Mean (SD) | 57 (8) | 53 (7) | 50 (7) | 46 (7) | <.0001 | |
| Social Role Satisfaction Mean (SD) | 40 (7) | 46 (7) | 51 (8) | 57 (8) | <.0001 | |
| Pain Interference Mean (SD) | 62 (8) | 53 (8) | 48 (8) | 44 (6) | <.0001 | |
| Total IBD | Anxiety Mean (SD) | 62 (8) | 55 (8) | 51 (8) | 45 (7) | <.0001 |
| Depression Mean (SD) | 60 (9) | 53 (8) | 49 (7) | 44 (5) | <.0001 | |
| Fatigue Mean (SD) | 66 (8) | 58 (8) | 52 (8) | 44 (8) | <.0001 | |
| Sleep Disturbance Mean (SD) | 58 (8) | 53 (7) | 51 (7) | 46 (7) | <.0001 | |
| Social Role Satisfaction Mean (SD) | 40 (7) | 46 (7) | 51 (7) | 57 (8) | <.0001 | |
| Pain Interference Mean (SD) | 62 (7) | 54 (8) | 49 (8) | 44 (6) | <.0001 |
#
Patient Reported Outcome Information Measurement System items are calibrated so that the mean of the US general population is 50 and the standard deviation is 10. Higher scores indicate more of the domain being measured.
&
Short IBD questionnaire (SIBDQ) scores range from 10 to 70 with 10 associated with lower health-related quality of life.
^
p values are from a non-parametric test of trend for the ranks of across ordered groups