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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Pharmacogenomics. 2014 Nov;15(14):1823–1838. doi: 10.2217/pgs.14.134

Table 2.

SULT1A1 genetic variation in vitro and therapeutic agents.

Study (year) Drug SULT1A1 source Main findings Ref.
Zheng et al. (2010) Aminoflavone Chinese hamster V79 cells stably coexpressing CYP1A1*1 with either SULT1A1*1, *2 or *3 IC50*3 > *1 > *2 [28]
Edavana et al. (2011) Fulvestrant 104 liver cytosols (Cooperative Human Tissue Network) Significant correlation between fulvestrant sulfation and SULT1A1*1/2 genotype and copy number [29]
Edavana et al. (2012) 4-OH toremifene 104 liver cytosols (Cooperative Human Tissue Network) Significant trend with SULT1A1 3′-UTR haplotypes and activity
Significant increase in activity with increasing copy number		 [30]