Table 4.
SULT1A1 genetic variation, smoking (polycyclic aromatic hydrocarbon exposure) and cancer risk.
| Study (year) | Cancer site | Population | Cases/controls (n) | Main findings | Ref. |
|---|---|---|---|---|---|
| Liao et al. (2012) | Lung | Mixed (meta-analysis) | 1669/1890 | Significantly increased risk with SULT1A1*2, but NA between smokers and nonsmokers | [61] |
| Li et al. (2012) | Lung and esophageal | Mixed (meta-analysis) | 1867/1785 | Marginally increased risk with SULT1A1*2 and smoking. Asian smokers had a stronger association | [64] |
| Arslan et al. (2009) | Lung | Turkish | 106/271 | Significantly increased risk with SULT1A1*2, but NA between smokers and nonsmokers | [62] |
| Liang et al. (2004) | Lung | Han Chinese | 805/809 | Significantly increased risk with SULT1A1*2 and smoking. Risk increased with smoking dose | [65] |
| Arslan et al. (2011) | Prostate | Turkish | 104/151 | NA | [63] |
| Li et al. (2012) | Colorectal | Mixed (meta-analysis) | 1867/1785 | NA | [64] |
| Cleary et al. (2010) | Colorectal | Canadian (Ontario Familial Colorectal Cancer Registry) | 1174/1293 | Significantly increased risk with SULT1A1*1/*1 and smoking >15 years | [66] |
| Lilla et al. (2007) | Colorectal | German | 505/604 | Significantly increased risk with SULT1A1*2 and 30+ pack-years of active smoking | [51] |
| Figueroa et al. (2008) | Bladder | Spanish Bladder Cancer Study | 1150/1149 | NA | [67] |
| Fortuny et al. (2006) | Bladder | Spanish | 958/1029 | NA | [68] |
| Kellen et al. (2006) | Bladder | Belgian | 200/385 | NA | [69] |
| Wang et al. (2008) | Bladder | Taiwanese | 300/300 | Significantly increased risk with SULT1A1*1/*1 and NQO1 C/T and T/T genotypes among ever-smokers | [70] |
| Wang et al. (2008) | Bladder | Taiwanese | 300/300 | Significantly increased risk with SULT1A1*1/*1 and exposure to more than one item of hazardous chemicals. Greater significantly increased risk with SULT1A1*1/*1 and heavy smoking. Greatest significantly increased risk with SULT1A1*1/*1 and exposure to more than one item of hazardous chemicals among ever-smokers | [71] |
| Santos et al. (2012) | Oral | Brazilian | 202/196 | Significantly increased risk with SULT1A1*1/*1 and smoking | [72] |
| Suzuki et al. (2008) | Pancreatic | Gastrointestinal Center at University of Texas MD Anderson Cancer Center | 755/636 | NA | [73] |
NA: No association.