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. 2015 Feb 20;11:273–279. doi: 10.3762/bjoc.11.31

Table 2.

Preparation of derivatives.a

graphic file with name Beilstein_J_Org_Chem-11-273-i001.jpg
Compound Precursor diol (8) rac:meso ratio R1 R2 Yield (7) [%]
7a 1.6:1.0 H H 85
7b 1.9:1.0 OMe OMe 47
7c 4.8:1.0 CF3 H 56
7d 1.8:1.0 OMe H >99
7e 1.6:1.0 F H 29
7f 1.0:1.1 H CF3 44
7g 1.0:1.2 H OMe 38
7h 1.0:1.6 H t-Bu 22
7i 1.0:1.0 – – 38
7j 1.0:2.0b – – 50

aFrom diol precursor (0.45 mmol) in THF (5.0 mL), with LiHDMS (2.0 equiv), CS2 (3.0 equiv), MeI (8.0 equiv), isolated yields. bEquivalent anti:syn ratio for 8j.