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. 2015 Feb 17;125(3):968–971. doi: 10.1172/JCI80280

Figure 1. The KLF family of transcription factors.

Figure 1

(A) KLF family members all contain three highly conserved zinc finger domains within their C terminus that bind to GC-rich regions in DNA. These three zinc finger domains insert into the major groove of the DNA helix. (B) KLF transcription factors generally bind proximal to the transcriptional start site, acting as transcriptional promoters. In the case of KLF4 bound to the angiotensin II receptor type 1 gene, the binding of SP1 confers inhibition of transcription. In the presence of TGF-β, SP1 dissociates from KLF4 and PPARγ binds, which promotes transcriptional initiation.