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. 2015 Feb 9;125(3):1228–1242. doi: 10.1172/JCI77656

Figure 5. EP3 mediates accumulation of ECM proteins in PAs in response to hypoxia.

Figure 5

(A–C) Immunofluorescence staining (red) of fibronectin (FN), collagen I (COL1), and tenascin C (Tn-C). Slides were double stained with α-SMA (green) and counterstained with DAPI (blue) for nuclei. Scale bars: 20 μm. (D–G) Relative mRNA levels of Fn, collagen 1α1 (Col1a1), collagen 1α2 (Col1a2), and Tn-C (Tnc) in lungs from normoxia- or hypoxia-treated Ep3–/– and WT mice (n = 4). *P < 0.05 versus WT and #P < 0.05 versus normoxia by 2-way ANOVA with Bonferroni’s post-hoc analysis.