Figure 5.

Apoptosis in tumors. Apoptotic dead was evaluated using terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining on CT26 tumor model grown on Balb/c mice. Tumors were removed from mice at various time points following treatment; paraffin-embedded and stained sections were examined microscopically. TUNEL stained for evidence of apoptotic cells indicate significant apoptosis in the tumor treated with pEEV lacZ and pEEV backbone but not from untreated groups.