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. 2014 Aug 6;1:14032. doi: 10.1038/mtm.2014.32

Figure 7.

Figure 7

Progressive behavioral impairment in mice that received DC injection of ssAAV9 vectors expressing ATXN1(Q141). Four-week-old C57BL/6 mice received an injection of phosphate-buffered saline (PBS) or ssAAV9 vectors expressing ATXN1(Q141) or GFP. (a,b) The motor coordination of the mice was tested with a rotating rod. Mice underwent four trials per day on both the accelerating (a) (4–40 rpm) rotarod and subsequently the constant (b) (20 rpm) rotarod immediately before and every week up to 8 weeks after the injection. The rotarod performances of the mice expressing mutant ATXN1 (n = 6 mice) were compared with those of the mice treated with PBS (n = 6) or the mice expressing GFP (n = 6). (c) Body weights of mice from the three experimental groups. Asterisks and daggers indicate statistically significant differences compared with the PBS-injected mice and the mice injected with ssAAV9 vectors expressing GFP, respectively, as determined by one-way analysis of variance followed by Tukey’s post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001, ††P < 0.01, and †††P < 0.001.