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. 2014 Jul 16;1:14026. doi: 10.1038/mtm.2014.26

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Copyright © 2014 The American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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Distribution and fate of Mreg_UKR in NSG mice. Recipient mice were given 5 × 10⁶ viable M regs or vehicle-only by slow intravenous injection. The tissue distribution of M regs was then assessed on days 1 to 7 post-injection by flow cytometry. Human M regs defined by expression of human CD45, CD11b and HLA-DR were detected in lung, blood and liver at all timepoints. Although the engrafted M regs remained CD14^-, CD16 expression was regained by day 1. Data are representative of at least two animals per timepoint from at least two independent experiments.