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. 2014 Jul 16;1:14026. doi: 10.1038/mtm.2014.26

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Copyright © 2014 The American Society of Gene & Cell Therapy

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Assessing the immunogenicity of allogeneic mouse M regs in mice. BALB/c mice were either treated with 5 × 10⁶ C3H-derived M regs (n = 4) or received no cells (n = 3). Eight days later, all mice were given a heterotopic heart transplant from a C3H donor. None of the transplants failed before day 7. On day 7, sera were harvested from all mice for measurement of antidonor IgG and IgM antibody titers by flow cytometry crossmatch. Mice treated with M regs 8 days before transplantation registered significantly lower levels of antidonor IgG than untreated controls (Mann–Whitney U-test; *P < 0.001). Gray line indicates limit of detection..