Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 2;1:14027. doi: 10.1038/mtm.2014.27

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 The American Society of Gene & Cell Therapy

This work is licensed. under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

PMC Copyright notice

The SCT molecule comprises an epitope, human β2m and HHD with the H74L mutation. (a) Structure of the SCT molecule with the H74L mutation (SCT-H74L). LS: leader sequence; huβ2m: human β2m; α1, α2, α3: α1, α2, α3 domains; Tm: transmembrane domain; Cyt: cytoplasmic domain. (b) Diagram of SCT-H74L on the cell surface. (c) Expression of SCT-HHD or SCT-H74L on the surface of RMA-S cells. RMA-S and RMA-S transfectants were stained with the anti-HLA-A*02:01 mAb, followed by FITC-labeled goat antimouse IgG antibody. Thick lines: RMA-S-HHD, peptide-pulsed RMA-S-HHD (pulsed with 1 μmol/l FMP_58–66), RMA-S-expressing SCT-HHD (RMA-S-SCT-HHD), and RMA-S-expressing SCT-H74L (RMA-S-SCT-H74L); Thin lines in all panels: RMA-S.