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EC4-Fc reduces atherosclerotic plaque area and incidence of buried layers. (a) Representative elastin van Gieson stained plaques. Bar = 250 µm. (b) Analysis of plaque area, an average was taken from four measurements along the brachiocephalic artery. (c) Analysis of buried layers. “Unstable” plaques have at least one buried layer, “stable” plaques have none. Mean + SEM, Fc n = 15, SNC n = 12, EC4 n = 15, *P < 0.05 versus Fc). EC, extracellular; SNC, soluble N-cadherin.
