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. 2014 Sep 10;1:14040. doi: 10.1038/mtm.2014.40

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed. under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Following intravascular injection of AAV9 at E14 with a GFP reporter gene, a mouse examined at P30 under a fluorescent stereomicroscope reveals GFP positive muscles of the (a) upper body, (b) lower body, Panniculus carnosus (PC) muscle underneath the (c) skin, (d) intercostal muscles, (e) diaphragm (Image taken from above the diaphragm) and (f) muscles of the face. Injection at (g) E12 and (h) E14 result in expression of the endocardium of the heart. Injection at (i) E16 and (j) P1 result in expression throughout the entire myocardium. Tibialis anterior muscle, following intravascular injection at (k) E12, (l) E14, (m) E16, and (n) P1. (o–q) E12 injection results in GFP expression in slow twitch fibers (Mab 484 shown in red). (r) E14 injection results in GFP positive myofibers up to 1 year of age.