Table 1.

Reported responses of individual cell lines to excitotoxicity and oxidative glutamate toxicity.

Cell lines	Excitotoxicity	Oxidative glutamate toxicity	Glutamate dose range	Time range of glutamate incubation
PC12	+	+	10 μM–10 mM	0.5–72 h1
SH-SY5Y		+	8–80 mM	0.5–48 h2
HT22		+	4–8 mM	3–48 h3
NT-2	+	+	10 μM–10 mM	4–58 h4
OLCs	+		50 μM–2 mM	12–24 h5
C6	+	+	10 μM–10 mM	1–28 h6
Primary astrocytes		+	2–5 mM	24–72 h7
PCRNs	+	+	1–5 mM	6–15 h8
RGC-5	+	+	1–25 mM	24–48 h9
SCN2.2	+		10 mM	>48 h10
GT1-7	+		10 mM	>48 h10

(+) positive for trait. ¹(Casado et al., 1996; Pereira and Oliveira, 1997, 2000; Penugonda et al., 2006; Pourzitaki et al., 2007, 2008, 2009; Lu et al., 2011); ²(Yoshioka et al., 2000; Sun et al., 2010; Hu et al., 2012; Park et al., 2012; Nampoothiri et al., 2014); ³(Davis and Maher, 1994; Stanciu et al., 2000; Gursoy et al., 2001; Zhang and Bhavnani, 2006; Xu et al., 2007; Landshamer et al., 2008; Tobaben et al., 2011; Kumari et al., 2012); ⁴(Munir et al., 1995; Sandhu et al., 2003); ⁵(Oka et al., 1993; Yoshioka et al., 2000); ⁶(Han et al., 1997; Sribnick et al., 2006; Castillo et al., 2010a); ⁷(Oka et al., 1993; Obara-Michlewska et al., 2014); ⁸(Stanciu et al., 2000; Zhang and Bhavnani, 2006); ⁹(Aoun et al., 2003; Fan et al., 2006; Van Bergen et al., 2009); ¹⁰(Karmarkar et al., 2011; Karmarkar and Tischkau, 2013).