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. 2015 Mar 16;208(6):683–692. doi: 10.1083/jcb.201411041

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© 2015 Li et al.

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Figure 2. — Conditional mutations in six embryonically essential dynein components. (A, left) The essential dynein subunits and known IFT–dynein components across species. (A, right) Gene models of dyci-1, dlc-1, dli-1, dylt-3, dyrb-1, and lis-1. Exons are in blue and red arrows indicate one or two sgRNA sequences targeting dynein components (Table S4). Bars, 300 bp. (B) Representative gels showing the results of T7EI assays. One target site generated two small fragments. (C) Embryonic lethality was determined by quantifying viable embryos after heat-shock treatment. n = 97–242; mean ± SE (error bars); *, P < 0.05; **, P < 0.01.