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. 2015 Mar 16;208(6):777–789. doi: 10.1083/jcb.201408087

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© 2015 Donninger et al.

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Figure 7. — NORE1A scaffolds p53 and HIPK2. (A) NORE1A forms a Ras-regulated complex with endogenous p53. HEK-293 cells were transfected with NORE1A in the presence or absence of activated Ras. Cells were lysed, immunoprecipitated (IP) for NORE1A, and immunoblotted (IB) for p53. (B) NORE1A promotes the formation of a p53–HIPK2 complex. HEK-293 cells were transfected with HIPK2, NORE1A, and activated Ras. Cells were lysed and immunoprecipitated (IP) for GFP-HIPK2. The IP was then examined for the presence of endogenous p53.