Table 3.
5-HT2A receptors in comorbidity between epilepsy and depression.
| Model | Effect | Reference | |
|---|---|---|---|
| Lamotrigine | Chronic pain states in rats | + m-CPP (5-HT2A/2B/2C) increased the reflex inhibitory action of lamotrigine | Than et al. (2007) |
| Lamotrigine | Chronic pain states in rats | Decreased the reflex inhibitory action of + Ketanserin (5-HT2A) lamotrigine | |
| Lamotrigine | Humans | Bipolar disorders | Bowden et al. (2003) |
| Lamotrigine | WAG/Rij rats | Suppression of AS and amelioration of comorbid anxiety and depression | Huang et al. (2012) |
| Aripiprazole (5-HT2A/5-HT6 antagonist) | WAG/Rij rats | Suppression of AS amelioration of comorbid anxiety depression and memory impairment | Russo et al. (2013) |
| Valproate | Humans | Increases 5-HT2A-R expression | Green et al. (1985); Sullivan et al. (2004) |
| Valproate | ECS | Inhibited impairment of spontaneous alternation behavior | Hidaka et al. (2011) |
| SSRIs (5-HT-R?) | Different models | Anticonvulsant | Specchio et al. (2004) |
| Ketanserin (5-HT2A antagonist) | ECS | Inhibited the impairment of short-term memory | Hidaka et al. (2010) |
| Ketanserin (5-HT2A antagonist) | ECS | Inhibited electroconvulsive shock-induced retrograde amnesia | Genkova-Papazova et al. (1994) |
WAG/Rij, Wistar Albino Glaxo rats from Rijswijk; ECS, electroconvulsive shock.