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. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Ultrasound Med Biol. 2015 Apr;41(4):905–928. doi: 10.1016/j.ultrasmedbio.2014.11.019

Table 4.

Opening of blood-brain barrier with pulsed focused ultrasound and microbubbles in rodents

Brain	Insonation parameters			Reference
	MHz	W.cm⁻²	MPa
Normal brain
	0.4	5.0-10.0	0.98-1.35	Liao et al 2012
	-	-	0.45-0.60	Chen et al 2013
	1.5	-	0.45-0.60	Samiotaki &Konofagou 2013

Implanted brain tumor
glioma	0.4	1.0-10.0	0.45-1.35	Liu et al 2010
breast cancer	0.69	0.32	0.69	Park et al 2012
glioma	1.0	-	0.7	Ting et al 2012
gliosarcoma	1.7	-	1.2	Treat et al 2012
glioma	0.69	-	0.55-0.81	Aryl et al 2013
glioma	0.40	4.0	0.325	Fan et al 2013[a]
glioma	1.0	3.0	0.6	Wei et al 2013
glioma	0.61	-	0.4	Kovacs et al 2014
astrocytoma (unfocused US)	0.5	-	0.4	II

Key: US = ultrasound

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