Table 6.
Antivascular ultrasound therapy of tumors in presence of circulating microbubbles
| Type of microbubble | tumor | Insonation parameters | Reference | |||
|---|---|---|---|---|---|---|
| MHz | W.cm−2 | PW/CW | MPa | |||
| Unloaded | ||||||
| melanoma | 1.0-3.0 | 2.0 | CW | 0.28 | Wood et al 2005,2006,2007,2008,2010 | |
| 3 tumor types | 1.0 | - | PW | 0.74 | Goertz et al, 2008,2009 | |
| adenocarcinoma | 1.2 | - | PW | 5.0 | Chin et al 2009 | |
| colon carcinoma | 1.5 | 133* | - | - | Zhong et al 2010 | |
| glioma | 1.0 | - | PW | 1.0-1.2 | Burke et al 2011 | |
| adenocarcinoma | 1.0 | 2.0 | PW | - | Lin et al 2012[a] | |
| Walker-256 | 0.83 | 0.4, 1.36 PW | 2.6, 4.8 | Liu et al 2012 | ||
| colon carcinoma | 0.24 | - | PW | 0.5 | Huang et al 2013 | |
| hepatoma | 1.75 | 539 | - | - | Wang et al 2013 | |
| breast cancer | 5.0 | - | PW | 4.0 | Hu et al 2012 | |
| epidermoid | 1.22 | 0.89 | PW | 4.6 | Peijing et al 2014 | |
|
| ||||||
| Unloaded +antianglogenic genes | prostate | 1.0 | 2.0 | PW | - | Duvshani-Eshet et al 2007 |
| hepatoma | 1.0 | 2.0 | PW | - | Nie et al 2008 | |
|
| ||||||
| Loaded | ||||||
| docetaxel | squamous carc. | 0.3 | 2.0 | - | - | Kang et al 2010 |
| II | prostate | 1.0 | - | PW | 1.65 | Goertz et al 2012 |
| doxorubicin | breast cancer | 3.0 | 2.0 | PW | - | Rapoport et al 2007 |
| II | colorectal | 1.0 | 2.0 | PW | 0.6 | Lin et al 2012b |
| carmestine +antiangiogenic complex | glioma | 1.0 | - | PW | 0.5 | Fan et al 2013 |
| antiangiogenic agent | colon cancer | 0.24 | - | PW | 0.5 | Zhang et al 2014 |
Key: PW= pulsed wave; CW = continuous wave; - = details not provided; carc. = carcinoma
*
= estimated;