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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Mol Cancer Res. 2015 Jan 7;13(1):9–15. doi: 10.1158/1541-7786.MCR-14-0076

Figure 2. CD44 induces EMT and is required for invasion in pancreatic cancer cells.

Figure 2

(A) qRT-PCR analysis for CD44 in iKras*p53*#1a cells transfected with control or CD44s expression vector (left) and morphology change of iKras*p53*#1a cells expressing control or CD44s vector (right). (B) qRT-PCR analysis for EMT genes. (C) qRT-PCR analysis for cells transfected with control siRNA or anti-CD44 siRNA. (D) Collagen invasion assay. (E) H&E staining of pancreas (top) and liver (bottom) following orthotopic transplantation of control shRNA or anti-CD44 shRNA infected iKras*p53*#1b cells. Quantification of the metastatic area.