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. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: Mol Cancer Res. 2015 Jan 7;13(1):9–15. doi: 10.1158/1541-7786.MCR-14-0076

Figure 3. A CD44-Snail1-MT1-MMP axis regulates pancreatic cancer invasion.

Figure 3

(A) MT1-MMP mRNA level upon CD44 knockdown alone or combined with re-expression of Snail1. p < 0.01. (B) Collagen invasion assays in control cells, or cells treated with a MT1-MMP siRNA or inhibitor. (C) Collagen invasion assays upon CD44 knock-down alone or combined with re-expression of MT1-MMP. (D) CD44S expression in the resected human pancreatic cancer and matched adjacent uninvolved pancreas. (E) CD44S and MT1-MMP expression in human pancreatic cancer cell lines. (F) Matrigel invasion assay (left) of human pancreatic cancer cell lines treated with MT1-MMP inhibitor and quantification (right).