TABLE 2.
Patient and tumor characteristics by subtype*
| Clinicopathologic variable | HR+/HER2- | HR+/HER2+ | HR-/HER2+ | HR-/HER2- | p-value |
|---|---|---|---|---|---|
| N | 8526 | 928 | 625 | 1517 | <.0001 |
| 74% | 8% | 5% | 13% | ||
| Age | |||||
| No. missing | 0 | 0 | 0 | 0 | |
| Median (range) | 57.5 (22–96) | 51.5 (21–89) | 53.3 (25–90) | 54.9 (19–95) | <.0001 |
| Tumor size | |||||
| No. missing | 142 | 18 | 17 | 40 | |
| Median (cm) | 1.3 | 1.5 | 1.6 | 1.7 | <.0001 |
| LVI | |||||
| No. missing | 0 | 0 | 0 | 0 | |
| % Yes | 28% | 43% | 40% | 32% | <.0001 |
| Grade ** | |||||
| No. missing | 253 | 38 | 41 | 45 | |
| % High grade | 25% | 63% | 89% | 86% | <.0001 |
| Nodal involvement | |||||
| No. missing | 0 | 0 | 0 | 0 | |
| % ≥ 1 positive LN | 40% | 49% | 53% | 41% | <.0001 |
| % ≥ 4 positive LN | 9% | 16% | 22% | 13% | <.0001 |
*
Percentages and statistical tests are based on available data for subtypes.
**
Nuclear grade when available, otherwise histologic grade. Classic lobular histology was assigned low grade.
LVI, lymphovascular invasion; LN, lymph node