TABLE 3.
Multivariate logistic regression of LVI (n = 11,025) (Covariates = subtype, tumor size, grade, age)
| Variable | Outcome | ||
|---|---|---|---|
| LVI | |||
| Adjusted OR (95% CI) | p-value | ||
| Subtype | HR-/HER2- | 1.0 | <.0001 |
| HR+/HER2- | 1.8 (1.6–2.1) | ||
| HR+/HER2+ | 2.5 (2.0–3.0) | ||
| HR-/HER2+ | 1.7 (1.4–2.1) | ||
| Tumor size (cm) * | 1.8 (1.7–1.9) | <.0001 | |
| Grade ** | Low/intermediate | 1.0 | <.0001 |
| High | 2.1 (1.9–2.4) | ||
| Age | 0.983 (0.980–0.987) | <.0001 | |
*
Odds of outcome occurrence with a 1 cm increase in tumor size.
**
Nuclear grade when available, otherwise histologic grade. Classic lobular histology was assigned low grade.
LVI, lymphovascular invasion; CI, confidence interval; OR, odds ratio