Figure 3.

Glucose control and insulin sensitivity during MMGTT in liraglutide- and placebo-treated GIPR ^dn transgenic pigs. (A) Plasma glucose levels and AUC glucose as well as (B) plasma insulin levels and AUC insulin and (C) plasma glucagon levels and AUC glucagon during MMGTT in 18-hour fasted GIPR^dn transgenic pigs after the 90-day treatment period, 0 min. = point of glucose administration. (D) Insulin sensitivity indices prior to (2-month-old pigs) and after the treatment period (5-month-old pigs), mo = months of age, n = number of animals investigated. Data are means ± SEM. For statistical analysis (ANOVA; Linear Mixed Models; SAS 8.2), data were square-root transformed. *: p < 0.05, **: p < 0.01, ***: p < 0.001.