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. 2015 Mar 10;15:35. doi: 10.1186/s12862-015-0327-z

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© Simonti et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The human RNA polymerase II subunit 1 (RPB1) C-terminal domain (CTD) contains more heptad repeats than the yeasts, and eight of its non-consensus distal repeats have a lysine residue. In this schematic of the RPB1 CTD for two species of yeast and human, consensus heptad repeats (YSPTSPS) are colored dark gray; repeats with a lysine at position 7 are colored red; and all other non-consensus repeats are in white.