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. 2014 Nov 28;2:22. doi: 10.1186/2050-7771-2-22

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© Jiang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Differential expression of IGF-IR, Rap1, and Vav2 in DCIS, DCIS with microinvasion, DCIS/LCIS with invasion >1 mm. (A) Representative monochrome images of Vav2 staining in normal mammary epithelium, DCIS, DCIS/T1mic, DCIS/IDC, and IDC. Original magnification (x200). Insets, enlarged images of epithelial cells. Arrows, suspected microinvasion. (B) Box plots for unaggregated measurements of IGF-IR, Rap1, and Vav2 in the groups of tissue: normal mammary epithelium, DCIS, DCIS/T1mic, and DCIS/IDC + LCIS/ILC. +, mean value. Horizontal lines, medians. Boxes, 25^th and 75^th percentile. Whiskers, 75^th +1.5 x IQR and 25^th -1.5 x IQR. Dots, group outliers. Y axis, protein levels in relative units. (C) The ROC curves for averaged measurements of IGF-IR, Rap1, and Vav2 protein expression.