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. 2015 Mar 11;9:1459–1467. doi: 10.2147/DDDT.S74989

Figure 3.

Figure 3

Synthesis of the target compounds 1a–r.

Notes: Conditions: (a) Et3N, benzylamine, EtOH, Et3N, reflux, 5 hours, 72%; (b) propargyl bromide, KI, K2CO3, CH3CN, rt, 5–6 hours, 81%; (c) NaN3, substituted benzyl bromide, dimethyl sulfoxide, CuSO4·5H2O, sodium ascorbate, rt, 12 hours, 60%–70%.