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Synthesis of the target compounds 1a–r.
Notes: Conditions: (a) Et3N, benzylamine, EtOH, Et3N, reflux, 5 hours, 72%; (b) propargyl bromide, KI, K2CO3, CH3CN, rt, 5–6 hours, 81%; (c) NaN3, substituted benzyl bromide, dimethyl sulfoxide, CuSO4·5H2O, sodium ascorbate, rt, 12 hours, 60%–70%.
