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Excitotoxicity induced by excess glutamate.
Notes: Extensive stimulation of NMDARs by glutamate leads to high level of Ca2+ to enter the cell, activating enzymes including phospholipases, endonucleases, and proteases. These enzymes may lead to apoptosis of the cell.
Abbreviation: NMDAR, N-methyl-D-aspartic acid receptor.
