Table 14.27.3.

Pre-Clinical Therapeutic Targeting of NSCLC Using Lung Orthotopic Tumor Models

Therapeutic agent	Cell line(s)	Effects	Reference
Cis-diamine dichloro platinum	Lewis lung carcinoma	Inhibits primary tumor growth and metastasis to the mediastinal lymph nodes	Doki et al. (1999)
Selumetinib	NCI-H441 and NCI-H460	Inhibits primary lung tumor growth and, to a lesser degree, lymph node metastases. Enhanced tumor activity when used in combination with cediranib	Takahashi et al. (2012)
Cediranib	NCI-H441 and NCI-H460	Inhibits primary lung tumor growth and, to a lesser degree, lymph node metastases. Enhanced tumor activity when used in combination with selumetinib	Takahashi et al. (2012)
Paclitaxel	NCI-H358 and PC14PE6	Decreases lung tumor burden	Onn et al. (2003)
Auranofin	H1703 and H1299	Inhibits primary lung tumor growth	V.J. and A.P.F. (unpub. observ.; see Example study)