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Next-generation therapies (such as MC4R agonists) that stimulate the release of endogenous oxytocin in the brain (hypothalamus) could evoke more potent and targeted effects compared to intranasal oxytocin treatment. Combining oxytocin with behavioral therapy may maximize therapeutic potential. Brain regions affected by intranasal oxytocin include the medial prefrontal cortex, anterior insula, orbitofrontal cortex, amygdala, and the ventral striatum (orange).
