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. Author manuscript; available in PMC: 2015 Mar 17.
Published in final edited form as: Epileptic Disord. 2009 Sep 10;11(3):206–214. doi: 10.1684/epd.2009.0273

Figure 4.

Figure 4

An increase in excitatory drive onto GABAergic interneurons underlies enhanced activity of inhibitory systems in the hippocampus of Lis1 ± mice (from Jones and Baraban, 2007). A) Top: whole cell voltage-clamp recording of sEPSCs on a WT interneuron. Bottom: same cell recorded in current-clamp mode. B) Top: sEPSC recording from a Lis1 ± interneuron. Bottom: same cell recorded in current-clamp mode. C) Mean sEPSC frequency is increased in Lis1 ± interneurons (p < 0.05, Student’s t-test). D) Mean sEPSC amplitude is similar between WT and mutant mice. E) Mean sEPSC decay time is similar between WT and mutant mice.