Table 1.
Most significant associations found by GWAS in the recent IGAP (International Genomics of Alzheimer’s Project) meta-analysis.
| Loci | Odds ratio (OR) | Possible biological pathways | |
|---|---|---|---|
| BIN1 | Bridging integrator 1 | 1.22 | Endocytosis |
| PICALM | Phosphatidylinositol binding clathrin assembly protein | 0.87 | Endocytosis |
| CLU | Clusterin | 0.86 | Immune and complement systems/inflammatory response; cholesterol/lipid metabolism |
| CR1 | Complement component (3b/4b) receptor 1 (Knops blood group) | 1.18 | Immune and complement systems/inflammatory response |
| MS4A6A | Membrane-spanning 4-domains, subfamily A, member 6A | 0.90 | Immune and complement systems/inflammatory response |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | 1.15 | Immune and complement systems/inflammatory response; cholesterol/lipid metabolism |
| SORL1 | Sortilin-related receptor, L(DLR class) A repeats containing | 0.77 | Endocytosis; lipid transport |
| PTK2B | Protein tyrosine kinase 2 beta | 1.10 | |
| EPHA1 | EPH receptor A1 | 0.90 | Immune and complement systems/inflammatory response; cholesterol/lipid metabolism |
| HLA-DRB5-HLA-DRB1 | Major histocompatibility Complex, class II, DR beta 5 and DR beta 1 | 1.11 | Immune and complement systems/inflammatory response; cholesterol/lipid metabolism |
Ten most significant associations identified in the overall meta-analysis performed by the IGAP [14]. Loci are shown from the most to the least significant and ORs result from the overall meta-analysis of both GWAS stages, calculated for the minor alleles. The loci are represented by the genes thought to most probably have a role in AD pathogenesis as part of the biological pathways indicated in the right column [9].