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. Author manuscript; available in PMC: 2015 Mar 17.
Published in final edited form as: Gut. 2014 Jan 16;63(10):1658–1667. doi: 10.1136/gutjnl-2013-305281

Figure 2.

Figure 2

Interleukin (IL)-6, IL-8 and 17β-oestradiol stimulate matrix metalloprotease (MMP) activity of normal and polycystic human cholangiocytes. IL-6, IL-8 and oestrogens—present in high levels in the cystic fluid of patients with polycystic liver diseases (PCLDs)—increased MMP activity of both (A) normal and (B) polycystic human cholangiocytes in culture. On the other hand, growth factors present at high levels in the cystic fluid of patients with PCLDs (ie, vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), epidermal growth factor (EGF), epithelial derived neutrophil activating peptide 78 (ENA78) and growth regulated oncogene α (GROα)) did not affect MMP activity of both human cell cultures (A, B). n=5 in each group (number of wells analysed).