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. 2015 Mar 17;11(3):e1005012. doi: 10.1371/journal.pgen.1005012

Fig 3. Molecular pathways serially identified among patients with microcephaly phenotypes in two large cohorts.

Fig 3

(A) 12 copy variant genes drawn from 14 of 27 Nijmegen patients with Microcephaly that were identified using multiple functional genomics methods (KEGG, Gene Expression and GO) and cluster strongly (p = 0.04) in the Dapple protein-protein interaction network. (B) Genes (n = 51; Red)) that were copy number variant in 30 of 71 Decipher patients with Microcephaly were found to possess a significant number of interactions with the genes from panel A (Green) (p = 0.04), forming an extensive and intertwined microcephaly-associated molecular network.