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. Author manuscript; available in PMC: 2015 Mar 17.
Published in final edited form as: J Pathol. 2014 Jan 29;232(5):522–533. doi: 10.1002/path.4321

Figure 7.

Figure 7

Mutations in TP53 are associated with enhancement of transcriptional programs that drive S phase and mitotic progression. (A) Pictorial diagram showing increased expression of many kinetochore-associated genes in 0 WT TP53 tumors relative to 2 WT TP53 tumors. Diagram of kinetochore adapted from Musacchio and Salmon[35] shows many kinetochore-associated genes and genes that regulated mitosis. Degrees of red shading indicate the number of cancer types (out of ten analyzed) in which that gene is significantly upregulated in 0 WT TP53 tumors relative to 2 WT TP53 tumors. (B) Model showing different mechanisms by which p53 may effect E2F1, MYBL2, and FOXM1 activities in breast cancer.P53 may have direct and indirect suppressive effects on these cell cycle regulatory transcription factors.