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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Oncogene. 2014 Sep 15;34(26):3349–3356. doi: 10.1038/onc.2014.295

Figure 2. Domain architecture of human PARP1.

Figure 2

Human PARP1 contains 1014 residues of amino acid with the molecular weight of 116 kDa. N-terminal three zinc finger motifs (Zn1-3) recognize SSBs and DSBs, which induces the conformational changes of the Tryptophan-glycine-arginine rich (WGR) and Catalytic domains and activates the enzymatic activity of PARP1.