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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Oncogene. 2014 Sep 15;34(26):3349–3356. doi: 10.1038/onc.2014.295

Figure 4. The molecular mechanism of the recruitment of BRCA1 to DNA lesions.

Figure 4

BRCA1 and BARD1 form heterodimer via the interaction between the Ring domains. Upon DNA damage, PAR quickly recruits the BRCA1-BARD1 complex via the interaction with the BARD1 BRCT. The BRCT of BRCA1 is important for the stable retention of BRCA1/BARD1 complex at the sites of DNA damage through the interaction with Abraxas/CCDC98.