Table 6. Predicted midgut-specific targets *.
| miRNA | putative targets |
|---|---|
| mse-miR-1 | adenylsulfate kinase, calmodulin, copper transporter, HoxX, hydroxybutyrate dehydrogenase (m.24658), isochorismatase domain containing protein, lipase, mitochondrial succinate semialdehyde dehydro-genase, protein mesh, α-1,3-fucosyltransferase, glucocerebrosidase isoform 1, mannose-1-phosphate guanylyltransferase, selenoprotein M, vacuolar ATP synthase subunit S1, pyridoxal-phosphate dependent enzyme, pyridoxine 5′-phosphate oxidase, regucalcin, renin receptor like isoform 1, RING finger protein 181, serine protease (m.165170), sideroflexin, sterol carrier protein 2/3-oxoacyl-CoA thiolase, sugar transporter (m.45569), synaptobrevin, tetraspanin1, vacuolar ATP synthase 21 kDa proteolipid subunit, v-type proton ATPase subunit C, v-type proton ATPase subunit D, v-type proton ATPase subunit E, v-type proton ATPase subunit F, v-type proton ATPase subunit G |
| mse-miR-10a | adenylate cyclase, eIF2A, GP40, isovaleryl CoA dehydrogenase, metal transporter CNNM2 like, peripheral-type benzodiazepine receptor, protein canopy like, synaptic vesicle protein, SSR β subunit |
| mse-miR-137 | 4-nitrophenylphosphatase, ACBP, Acyltransferase, ADGF-like, Bombyrin precursor, CCDC, cytosolic malate dehydrogenase, enoyl CoA hydratase, glucose dehydrogenase, glutathione S-transferase 13, isocitrate dehydrogenase (m.30761), pancreatic lipase, prenyl-dependent CAAX metalloprotease, bhlhzip TF bigmax, carboxypeptidase A like, dipeptidyl peptidase, mitochondrial short-chain specific acyl-CoA dehydrogenase, zinc finger protein, pyroglutamyl peptidase 1, sugar transporter (m.222220), sugar transporter SWEET1, TPPP family protein, trypsin-like protease, v-type proton ATPase subunit D |
| mse-miR-263a | 2-deoxyglucose-6-phosphate phosphatase, acyl-CoA dehydrogenase, cadherin, carboxypeptidase B, dimeric dihydrodiol dehydrogenase, enoyl CoA isomerase, MCT (m.228787), nitrilase, protein mesh, RING finger and WD repeat domain-containing protein 3, sugar transporter (m.45569) |
| mse-miR-263b | AMP dependent CoA ligase, ecdysoneless, glucose dehydrogenase, HSP90 β, metal transporter CNNM2 like, protein cueball, amidase, bhlhzip TF bigmax, cAMP-dependent protein kinase catalytic subunit, lysosomal acid lipase, pyroglutamyl peptidase 1, retinol dehydrogenase |
| mse-miR-277 | 2-hydroxyphytanoyl-CoA lyase, ACBP homolog, AMP dependent CoA ligase, bombyrin precursor, chorion b-ZIP TF, cytochrome P450 (m.45481), flavin reductase, HSP105, inorganic pyrophosphatase, isocitrate dehydrogenase (m.30761), maggie, mitochondrial succinate semialdehyde dehydrogenase, peripheral-type benzodiazepine receptor, phosphotriesterase like, prohibitin WPH, protein cueball, α-1,3-fucosyltransferase, carbonic anhydrase, pyroglutamyl peptidase 1, regucalcin, SCOT, Sel1 repeat-containing protein 1 like, serpin 15A, sphingolipid Δ4-desaturase, TPPP family protein, transporter (m.87506), v-type proton ATPase subunit B |
| mse-miR-281 | 3-dehydroecdysone-3alpha reductase, carboxypeptidase 3, CRAL-TRIO domain-containing protein, cytochrome P450 6AE32, eIF2A, glutamate receptor, inorganic pyrophosphatase, isochorismatase domain containing protein, LRR, NADPH cytochrome P450 reductase, serpin 15A |
| mse-miR-283 | acyltransferase, adenylsulfate kinase, α-amylase, aminoacylase 1, aminopeptidase N-11, Bombyrin precursor, calmodulin isoform A, copper transporter, cytosolic malate dehydrogenase, ER lumen protein retaining receptor, FAMeT, fatty acid binding protein, glutamate receptor, GP40, hydroxysteroid dehydro-genase, isocitrate dehydrogenase (m.61421), kynureninase, LPP1, MSBP, peritrophic membrane chitin binding protein, alcohol dehydrogenase, cAMP-dependent protein kinase catalytic subunit, carbonic anhydrase, pyridoxine 5′-phosphate oxidase, SCP related protein, short chain type dehydrogenase (m.29729), sphingolipid Δ4-desaturase, sugar transporter (m.222220), synaptobrevin, trypsin alkaline D, trypsin-like protease, v-type proton ATPase subunit D |
| mse-miR-316 | 3-dehydroecdysone-3α reductase, Arg kinase, calmodulin isoform A, cytochrome b5, GP40, hatching enzyme like protein, hydroxybutyrate dehydrogenase (m.198924), kynureninase, LAP, mitochondrial cytochrome C oxidase subunit 6A, phosphoenolpyruvate synthase, alcohol dehydrogenase, regucalcin, SSR, succinyl-CoA ligase β chain, Toll9, TP53-regulated inhibitor of apoptosis 1-B |
| mse-miR-750 | organic cation transporter (m.212782), Pap-inositol-1,4-phosphatase, sodium-bile acid co-transporter, V-type proton ATPase subunit B |
| mse-miR-6094 | carboxyl cholinesterase, pancreatic lipase, peripheral-type benzodiazepine receptor, Ras family protein, short chain type dehydrogenase (m.29729), vacuolar ATPase subunit M9.7 |
| mse-miR-9571a | 2-deoxyglucose-6-phosphate phosphatase, ACBP, adrenodoxin, Bombyrin precursor, calcium-binding protein p22, copper transporter, cytosolic JH binding protein 36 kDa subunit, GP40, HoxX22, lipid storage droplet protein 2, mitochondrial carrier like, mitochondrial NADPH adrenodoxin oxidoreductase, neuro-peptide receptor A10, Pap-inositol-1,4-phosphatase, peptidyl-prolyl cis-trans isomerase, peroxisomal biogenesis factor 19, phosphoenolpyruvate synthase, bhlhzip TF bigmax, mitochondrial short-chain specific acyl-CoA dehydrogenase, Ras family protein, RGS-GAIP interacting protein GIPC, SCP related protein, sugar transporter SWEET1, transferrin3, trypsin-like protease, v-type proton ATPase subunit F |
| mse-miR-9571b | 2-deoxyglucose-6-phosphate phosphatase, ACBP, adrenodoxin, Bombyrin precursor, B. mori glutathione-S-transferase 4, B. mori glutathione-S-transferase 5, calcium-binding protein p22, carbonyl reductase, chitin binding domain 3 protein, copper transporter, fatty acid binding protein, glutathione S-transferase 13, His-triad nucleotide binding protein 3, hydroxybutyrate dehydrogenase (m.24658), isocitrate dehydrogenase (m.30761), kynureninase, MCT (m.94739), mitochondrial carrier like, MSBP, Pap-inositol-1,4-phosphatase, peripheral-type benzodiazepine receptor, α-1,3-fucosyltransferase, bhlhzip TF bigmax, lysosomal acid lipase, RAB6-interacting golgin like, vacuolar ATP synthase subunit S1, pyroglutamyl peptidase 1, Ras family protein, SCP related protein, serine protease (m.46246), short chain type dehydrogenase (m.81137), sugar transporter SWEET1, synaptic vesicle glycoprotein 2B, synaptobrevin, transporter (m.78218), v-type proton ATPase subunit F |
| mse-miR-9a* | chitin binding domain 3 protein, citrate synthase, cytochrome P450 4M1, ecdysoneless, glucose dehydrogenase, HoxX, lactoylglutathione lyase, LRR, metal transporter CNNM2 like, methylmalonyl-CoA carboxyltransferase 12S subunit, organic cation transporter (m.57266), peroxisomal biogenesis factor 19, harmonin, SCP related protein |
| mse-miR-10a* | glutathione S-transferase 13, HoxX22, methylcrotonoyl-CoA carboxylase 1α, NADPH cytochrome P450 reductase, dipeptidyl peptidase, SSR β subunit |
| mse-miR-281* | cytochrome c-like, isochorismatase domain containing protein, phosphoenolpyruvate synthase, bhlhzip TF bigmax |
| mse-miR-283* | 3-dehydroecdysone-3α reductase, eIF2A, O-acyltransferase, peroxisomal biogenesis factor 19, prenyl-dependent CAAX metalloprotease, bhlhzip TF bigmax, pyridoxal-phosphate dependent enzyme |
| mse-miR-316* | acetoacetyl-CoA thiolase, ARF, B. mori glutathione-S-transferase 4, cytochrome P450 6AE32, fatty acid binding protein, glutathione S-transferase 13, HoxX, innexin, isovaleryl CoA dehydrogenase, metal transporter CNNM2 like, ADK 3, regucalcin, retinol dehydrogenase, short chain type dehydrogenase (m.29729), v-type proton ATPase subunit C |
| mse-miR-750* | dimeric dihydrodiol dehydrogenase, lactoylglutathione lyase, methylcrotonoyl-CoA carboxylase 1α, NADPH cytochrome P450 reductase |
*
If gene names are the same, the transcript IDs (m. number) were included in the parentheses.