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. 2014 Nov 13;2:20. doi: 10.1186/2050-7771-2-20

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© Orro et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The Transdermal Analyses Patch (TAP). Panel A: TAP consists of a plaster with a nitrocellulose core that contains the capture antibody micro-array, which is clearly visible in the middle. Panel B: In the lower photo, TAP has been fixed to skin. In the upper photo, it is clearly visible that the layer in between the micro-array and the adhesive layer expands upon contact with fluid. This layer serves as a reservoir for the buffer used for biomarker extraction from skin, as well as to ensure close contact between capture antibody micro-array and skin during extraction.