Table 2.
Significantly over-represented INO terms among the gene-gene interaction pairs of vaccine-associated sub-network
| INO_ID | Reference term | Enrichment fold | BH * P-value |
Most frequent gene-pair (#) |
|---|---|---|---|---|
| INO_0000140 | Neutralization | 6.6 | 0 | IFNG_IL12A (5)** |
| INO_0000096 | induction of production | 6.2 | 0 | TNF_IFNG (2) |
| INO_0000106 | gene fusion | 5.6 | 0 | CD40LG_CD40 (3) |
| INO_0000103 | accessory regulation | 3.9 | 0 | CD8A_CD4 (55) |
| INO_0000062 | Costimulation | 3.7 | 0 | CD40_CD8A (4) |
| INO_0000169 | Synergization | 3.0 | 0 | CD8A_CD40 (5) |
| INO_0000089 | co-regulation | 2.9 | 0 | CD8A_CD40 (5) |
| MI_0559 | glycosylation reaction | 2.9 | 0 | IL17A_MUC6 (1) |
| MI_0195 | covalent binding | 2.5 | 0 | CSF2_ACPP (2) |
| MI_0208 | genetic interaction | 4.9 | 1.82E-10 | CD40LG_CD40 (3) |
| MI_0571 | mRNA cleavage | 23.2 | 2.58E-07 | CFI_SUPT5H (1) |
| MI_0902 | RNA cleavage | 16.2 | 2.21E-06 | CFI_SUPT5H (1) |
| MI_0910 | nucleic acid cleavage | 6.4 | 6.11E-04 | CFI_SUPT5H (1) |
| GO_0018377 | protein myristoylation | 2.3 | 2.68E-03 | CD4_S100B (2) |
*BH: Benjamini-Hochberg; **IFNG_IL12A (5): represents the IFNG and IL12A gene pair with the ‘neutralization’ interaction keyword in five papers.