Table II. Predictions and confirmations of the Novak-Tyson model of MPF control in frog egg extracts.
| Prediction# | Confirmation | |
|---|---|---|
| 0 | Cyclin threshold for MPF activation | (Solomon et al. 1990) |
| 1 | Cyclin threshold for MPF inactivation | (Pomerening et al. 2003, Sha et al. 2003) |
| 2 | Critical slowing down of MPF activation | (Sha et al. 2003) |
| 3 | Elevated cyclin threshold by unreplicated DNA | (Sha et al. 2003) |
| 4 | Relaxation oscillations in cycling extracts | (Pomerening et al. 2005) |
| 5 | Sinusoidal oscillations in Cdc2AF extracts | (Pomerening et al. 2005) |
| 6 | Propagating wave of MPF activation | (Chang & Ferrell 2013) |
#
0 is a “postdiction”; 1-6 are predictions. Predictions 1-5 are made in Novak & Tyson (1993b), and prediction 6 is described in Novak & Tyson (1993a).