Table 2.

Association of plasma Aβ levels with risk of incident dementia and Alzheimer’s disease

		Continuous (per SD)			Quartile 1		Quartile 2		Quartile 3		Quartile 4
		HR	95% CI	P	HR	95% CI	HR	95% CI	HR	95% CI	HR
Model A*
Aβ1-40	AD	0.93	[0.81–1.06]	2.59×10−01	1.29	[0.85–1.96]	1.71	[1.17–2.51]	1.28	[0.84–1.96]	Ref.
	Dementia	0.91	[0.81–1.03]	1.26×10−01	1.50	[1.03–2.19]	1.58	[1.10–2.27]	1.48	[1.01–2.16]	Ref.
Aβ1-42	AD	0.79	[0.69–0.90]	3.00×10−04	2.46	[1.60–3.78]	1.82	[1.18–2.81]	1.94	[1.26–3.00]	Ref.
	Dementia	0.80	[0.71–0.90]	2.00×10−04	2.20	[1.51–3.20]	1.52	[1.03–2.24]	1.66	[1.13–2.44]	Ref.
Aβ1-42/Aβ1-40 ratio	AD	0.83	[0.72–0.96]	1.23×10−02	1.59	[1.06–2.39]	1.58	[1.05–2.38]	1.38	[0.90–2.12]	Ref.
	Dementia	0.86	[0.76–0.98]	2.73×10−02	1.52	[1.05–2.20]	1.48	[1.02–2.14]	1.39	[0.95–2.04]	Ref.
Model B†
Aβ1-40	AD	0.93	[0.81–1.05]	2.51×10−01	1.30	[0.85–1.99]	1.78	[1.21–2.62]	1.33	[0.86–2.04]	Ref.
	Dementia	0.92	[0.82–1.03]	1.65×10−01	1.45	[0.99–2.12]	1.64	[1.14–2.36]	1.53	[1.04–2.24]	Ref.
Aβ1-42	AD	0.79	[0.69–0.90]	4.00×10−04	2.36	[1.53–3.64]	1.81	[1.17–2.81]	1.86	[1.20–2.87]	Ref.
	Dementia	0.81	[0.72–0.91]	6.00×10−04	2.06	[1.41–3.01]	1.53	[1.04–2.26]	1.63	[1.11–2.40]	Ref.
Aβ1-42/Aβ1-40 ratio	AD	0.84	[0.72–0.97]	1.55×10−02	1.58	[1.05–2.38]	1.47	[0.98–2.22]	1.29	[0.84–1.99]	Ref.
	Dementia	0.87	[0.77–1.00]	4.28×10−02	1.47	[1.01–2.12]	1.38	[0.95–2.00]	1.32	[0.90–1.93]	Ref.
Model C‡
Aβ1-40	AD	0.92	[0.81–1.05]	2.28×10−01	1.30	[0.84–2.01]	1.88	[1.27–2.78]	1.29	[0.83–2.00]	Ref.
	Dementia	0.92	[0.81–1.03]	1.44×10−01	1.44	[0.97–2.13]	1.73	[1.20–2.51]	1.49	[1.01–2.20]	Ref.
Aβ1-42	AD	0.79	[0.68–0.90]	5.00×10−04	2.31	[1.49–3.58]	1.67	[1.06–2.63]	1.75	[1.12–2.75]	Ref.
	Dementia	0.81	[0.72–0.92]	1.20×10−03	1.95	[1.32–2.87]	1.40	[0.94–2.09]	1.53	[1.03–2.27]	Ref.
Aβ1-42/Aβ1-40 ratio	AD	0.85	[0.73–0.98]	2.72×10−02	1.59	[1.05–2.40]	1.38	[0.91–2.09]	1.27	[0.81–1.99]	Ref.
	Dementia	0.89	[0.78–1.02]	8.57×10−02	1.44	[0.99–2.10]	1.27	[0.87–1.85]	1.29	[0.86–1.92]	Ref.

Abbreviation: AD, Alzheimer’s disease; HR, Hazard ratio; SD, Standard deviation; 95% CI, 95% Confidence interval; Ref., Reference

NOTE. Hazard ratios, confidence intervals and P-value were evaluated in Cox regression models

^*Model A: adjusted for age and gender

^†Model B: adjusted for age, gender, education and APOE ε4 status

^‡Model C: adjusted for age, gender, education, APOE ε4 status, prevalent hypertension, diabetes and cardiovascular disease, current smoking, total cholesterol levels, and being in the top sex-specific quartile of waist-hip ratio